Threshold of oestrogen and progesterone for endocrine therapy

In women with invasive breast cancer, the ECIBC's Guidelines Development Group (GDG) suggests:

  • administration of adjuvant endocrine therapy if 1% or greater of tumour cells show oestrogen receptor positivity rather than applying a threshold of 10% tumour cell oestrogen receptor positivity
    (conditional recommendation, very low certainty of the evidence)
  • administration of adjuvant endocrine therapy if 1% or greater of tumour cells show progesterone receptor positivity rather than applying a threshold of 10% tumour cell progesterone receptor positivity (conditional recommendation, very low certainty of the evidence)

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Multigene testing to guide the use of chemotherapy

To guide the use of chemotherapy in women with hormone receptor positive, HER2-negative, and lymph node negative or up to 3 lymph nodes positive invasive breast cancer, the ECIBC's Guidelines Development Group (GDG):

  • recommends not using the 70 gene signature test when women are at low clinical risk (strong recommendation, low certainty of the evidence)
  • suggests using the 70 gene signature test when women are at high clinical risk (conditional recommendation, low certainty of the evidence)
  • suggests using the 21 gene recurrence score (conditional recommendation, very low certainty of the evidence)

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